Sunday, November 11, 2012

Rebellious Queen all ready to win Ladbrokes.com 480 Bitches - Bettor

Rebellious Queen all ready to win Ladbrokes.com 480 Bitches

During the current season, Rebellious Queen has made a number of podium finishes that predominantly include victories. The P. Rosney trained white and black bitch has proved her class in various formats of game.

In the light of his excellent success streak of this season, the punters have picked the three-year-old veteran hound as the hot favourite candidate for tonight?s Ladbrokes.com 480 Bitches that will take place at Monmore racecourse on Saturday night, November 10.

The open race of ?200 is scheduled to be run over the distance of 480 metres. Rebellious Queen is going to visit Monmore after a long gap. Hopefully, she will be able to make a big impact over there.

The brilliant bitch has been winning with regular intervals since appearing in the sport arena. She has earned some iconic feats in her career.

The daughter of Head Bound out of Goodlucknow won a T2 race by the margin of 2 ? lengths on March 27. That was her first triumph of this season. She surprised all and sundry by winning another T2 contest with the huge margin of 10 ? lengths on April 10.

The young and enthusiastic runner made a classic hat-trick of victories in the month of October. Those were also T2 races.

Now, the bitch is keen to register an OR victory. Tonight?s race will be an ideal opportunity for her to do so. The only rival who can prove to be dangerous for her is Dixies Craft.

The C. Allsopp trained black bitch nicely won a T3 race by the margin of 12 ? lengths on September 4. She stepped forward to lift the ace title of the Romforddogs.com Maiden Stayers on September 12. Both were decent performances.

As a whole, the daughter of Head Bound out of Hondo On Air has a number of runner-up positions to her credit. She always tries to put up her utmost effort in every race.

As far as tonight?s contest is concerned, Dixies Craft will compete neck-to-neck with Rebellious Queen. The spar between the two will be really amazing to watch. Good luck to both the contestants.

Disclaimer: The views expressed in this article are the writer's own and do not reflect Bettor.Com?s editorial policy.

Source: http://blogs.bettor.com/Rebellious-Queen-all-ready-to-win-Ladbrokes-com-480-Bitches-a200330

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Personal Development Plans To Succeed In Academics | Oregon ...

An action strategy can be built using Personal development plans and this is comprised of knowledge, goals and merits. This strategy can be of any type like occupation, studies, relationships, self improvement. Personal enterprise plan and individual development plans are the other names for this. Various skills are needed to achieve the goals, this is the process to analyze and learn those skills.

It is the combination of strength and fault, preparation and teaching, many more points. The goal behind the strategy makes them differ with each other. Academics are related to learning habits, occupational view includes lifestyle imports, arrangements, examination of risks and future steps. This is comprised of a portfolio in higher education. This portfolio is the reference to the academic achievements and leads towards higher order of achievements in the future.

The concept of self motivated learning is also used successfully in human resource management. These are the building blocks of employee CVs and it can be observed that many business training programs insist the students to prepare an individual portfolio. Even the governments practice this concept by preparing a list of goals for five years and by trying to accomplish those goals. This is a program which works under certain time frame and the task should be completed within that period.

A person must know where he is heading or else the path chosen is of no use. It is important to build a strategy to reach the goals in desired time. Universal truth is to write down your goals and act that will lead you towards your destiny. As per the researchers, the accomplishment of the task is possible if you write down your task and follow the time frame.

The system developed to achieve the goals must have some important points and that points can be listed as clarity to give a perfect view about the goals, purpose to show the need of that specific task, directions to fulfill the requirements of that task. Following 3 point system saves a valuable time and energy. This ensures the accomplishment of the goals. Strategic plan guarantees the success, no wishful thinking can.

Both educational and occupational fields can make use of this formula. In academics, students get benefits and these benefits can be enumerated as clearer projection towards the learning, self motivation, better understanding and performance criteria, low stress and better skill development, greater problem facing ability and thinking reflectively. These all collectively cause better academic achievements.

Benefits of strategy writing in professional life can be summarized as, it provides a clearer view towards the life and job you deserve brings confidence to make choices, improvises eminence and expertise, gives confidence to talk about your excellence with the employers, optimized problem solving expertise can be attained, results in a positive attitude and effective professional life. Employers expect the employee to be committed towards the work assigned. Rapid learning and good performance are needed for a successful professional life.

Betterment of private life can be attained with this strategy design apart from academics and occupational fields. The impacts on private life can be enumerated as better understanding of him, reaching the ambitions with better choice, finding the ways to reach the goals etc. The concept is useful in private, academic and occupational fields. Personal development plans are the stairs to success.

Read more about Personal Development Plans To Succeed In Personal Life visiting our website.

Source: http://oregonattractions.net/attractions/personal-development-plans-to-succeed-in-academics/

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Source: http://rimibamuro.posterous.com/personal-development-plans-to-succeed-in-acad

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Source: http://chester1195.typepad.com/blog/2012/11/personal-development-plans-to-succeed-in-academics-oregon.html

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Source: http://lyons7166.typepad.com/blog/2012/11/personal-development-plans-to-succeed-in-academics-oregon.html

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More than 5,000 Syrian refugees cross into Turkey

ANKARA, Turkey (AP) ? ?A government official says more than 5,000 Syrians have crossed into Turkey overnight to flee the violence in their country.

An official at the government's crisis management center said Friday the Syrians crossed into the Turkish border provinces of Mardin, Sanliurfa and Hatay, raising the number of refugees in the country to close to 120,000. The official spoke on condition of anonymity in line with government rules.

Earlier, the state-run Anadolu Agency said a group of Syrian soldiers, including two generals and 11 colonels, had fled to Turkey with their families seeking refuge and were taken to a camp that shelters military defectors.

Source: http://news.yahoo.com/more-5-000-syrian-refugees-cross-turkey-104925840.html

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Saturday, November 10, 2012

ONGC shares fall as earnings miss estimates

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YMCA's in South Charlotte NC

YMCA,YMCA Charlotte NC, YMCA South Charlotte, YMCA's in South Charlotte,YMCAs in Charlotte NC,Siskey YMCA, Morrison YMCA,Harris YMCA, Ballanyne Village YMCA,sports and fitness in South Charlotte, South Charlotte lifestyle

When it comes to an?exceptional YMCA experience,?I?ve got to believe that the?YMCA?s in South Charlotte?are second to none! ?I moved to Charlotte, NC from the Washington, DC area, and trust me, the YMCA?s there were nothing to write home about! ?I was reluctant to check out the?YMCA?s in South Charlotte?because of that previous experience, but now I am a BELIEVER! ?The?YMCA?s in South Charlotte?offer an incredible lifestyle experience ? new, state-of-the-art facilities, a wide array of classes and activities, and a welcoming staff that create an inviting atmosphere. ?I have a few great South Charlotte YMCA?s to talk about:

YMCA,YMCA Charlotte NC, YMCA South Charlotte, YMCA's in South Charlotte,YMCAs in Charlotte NC,Siskey YMCA, Morrison YMCA,Harris YMCA, Ballanyne Village YMCA,sports and fitness in South Charlotte, South Charlotte lifestyle

Siskey YMCA

My family belongs to the?Siskey Family YMCA,?located at?3127 Weddington RD, Matthews, NC. ??I live in nearby?Providence Plantation,?and I can WALK to this awesome YMCA! ?Opened in 1996, the?Siskey Family YMCA?offers the following at its facility:

  • 6 lane indoor pool
  • Outdoor water park and lap pool
  • Flexibility studio for students of Yoga and Pilates
  • Fitness center with strength and cardio equipment
  • Free weight room
  • Family fitness room
  • Genesis Center ? a small fitness area that works well with beginners
  • Twin court gymnasium
  • Indoor and outdoor track
  • Sports fields
  • 2 group exercise studios
  • Adult and family locker rooms (adult locker rooms with steam and sauna)
  • Children?s center for child care
  • Carolinas Medical Center (CMC) Wellness Center with a full-time nurse
  • Youth center with a game room and fitness center
  • Chapel

?

The?Siskey YMCA?offers a wide variety of classes and sports activities for the whole family. ?Kids can enjoy sports and recreation, camp and lots of social activities such as?SNS, or Saturday Night at the Siskey,?which is an awesome social event for 6-8th graders on the first Saturday night of the month. ?4th and 5th grade Fun Night?occurs on the 2nd Saturday night of the month. ?These events offer a safe and wholesome opportunity for youth to come together and socialize, play ball and have fun!

Siskey Family YMCA hours are:

  • Monday ? Friday ?5:00 am to 9:30 pm
  • Saturday ? 7:00 am to 6:00 pm
  • Sunday ? 12:00 pm to 6:00 pm

YMCA,YMCA Charlotte NC, YMCA South Charlotte, YMCA's in South Charlotte,YMCAs in Charlotte NC,Siskey YMCA, Morrison YMCA,Harris YMCA, Ballanyne Village YMCA,sports and fitness in South Charlotte, South Charlotte lifestyle

Morrison Family YMCA

The Morrison Family YMCA?is located in the?heart of Ballantyne, at 9405 Bryant Farms RD, Charlotte, NC ?28277. ?This YMCA has similar facility offerings as the Siskey YMCA. ?Here is a sampling of activities at the?Morrison YMCA:

  • Youth: ?camps, birthday parties, teen activities, clubs, art, dance, tutoring, kids CPR, theatreAdults
  • Youth sports: ?flag football, soccer, volleyball, basketball, martial arts, cheerleading, T-ball
  • Adults: ?group fitness classes, healthy lifestyles, water activities, boxing, cancer wellness, cooking classes, CrossFit, Dance, health coaching,martial arts, massage, metabolic testing, nutrition, personal training, yoga and pilates, running/training, and a variety of sports

Morrison Family YMCA hours are:

  • Monday ? Thursday ?5:00 am ? 10:00 pm
  • Friday ? 5:00 am ? 9:30 pm
  • Saturday ? 7:00 am ? 6:00 pm
  • Sunday ? 12:00 pm ? 6:00 pm

Other South Charlotte YMCA?s

There are several other?South Charlotte YMCA?s?for you to check out. ?They offer similar facilities and activities. ?Find a South Charlotte YMCA that suits your family?s lifestyle and join in! ?When you join the YMCA in Charlotte, you?ll have access to?full use of ?19 locations in Mecklenburg, Union, Lincoln, Iredell Counties, including access to?all of our?outdoor pools and waterparks?in addition to the lakefront at the Lake Norman YMCA.

There are NO initiation fees! ?Find the program level that suits your family and take off!

South Charlotte Real Estate Expert

Buying or selling real estate in South Charlotte NC? is really about lifestyle choices ? finding the best neighborhood, home, school, and location to fit your family?s lifestyle.? That?s why it?s important to partner with a Realtor? who will really listen to your needs and goals and who will work tirelessly until your transaction is complete and beyond.? Whether you are thinking about selling your South Charlotte home, or would like to buy a home in South Charlotte, I look forward to showing you why I?m not your ordinary Realtor!? I use cutting-edge technology to market my listings and to attract home buyers who want that South Charlotte lifestyle!?

Let me put my knowledge and experience to work for YOU!? For more information on how I can best serve you, please fill out the online contact form or call, text, or email me.

Melissa Brown, ABR, SFR Helen Adams Realty 704-654-9700 Melissa@MelissaBrownHomes.com

Melissa Brown

Melissa Brown has written 38 posts in this blog.


Source: http://www.southcharlottelifestyle.com/ymcas-in-south-charlotte-homes-for-sale/

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A friggin awesome Real Time workout! - BODYROCK.tv | Fitness ...

How much time do we waste trying to fit a square peg into a round hole?

If you find yourself having to ?sell? how special you are to others then chances are you are talking to the wrong person. If you find yourself having to convince someone that you are trustworthy and decent, chances are that you are talking to the wrong person. If people don?t look at you and recognize you for the vibrant, decent and wonderful person you are ? chances are they are a square peg. Trying to convince others of your worth is heartbreaking and exhausting and in the end even if you temporarily manage to convince them it rarely lasts. Surround yourself with people who recognize you as a good person without the hard sell because in the end you can?t buy loyalty anyway.

Best,
Freddy.

Here is today?s Real Time Workout. Hit Replay at the end to do another full round with Lisa! Try for 3 rounds or more!

For the breakdown of exercises watch the video. Lisa takes you through the whole routine!!!!

Here is Lisa?s check in video ? watch this video for some warm up motivation and info about today?s workout!

Time: 12 MinWorkout Type: body weightExercises: 1

Nvidia's 3Q earns rise, company starts dividend

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Source: http://news.yahoo.com/nvidias-3q-earns-rise-company-starts-dividend-005000525--finance.html

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Toy Story: Veach's Celebrates 75 Years | My Indiana Home

November 9, 2012 By admin

Veach's Toy Station in Richmond

Step inside Veach?s Toy Station in downtown Richmond, and you?ll immediately understand why the toy store captivates the hearts of children young and old. With roughly 16,000 square feet teeming with toys, crafts, hobbies, puzzles, games, erector sets, science fair project kits and dress-up items, and an entire floor overrun with electric trains inviting you to play, the giant specialty store sells toys you won?t see anywhere else.

?Kids? jaws drop when they walk in,? says third-generation owner John Veach, whose grandfather founded the store in 1938. At Veach?s, you won?t find any video games, because the store focuses on educational toys for all ages with ?play value.? Here, kids can engage with toys powered by their own imaginations.

Veach?s has come a long way since Louis Veach opened the store as a five-and-dime department store and lunch counter, selling pots, pans, toys and hardware supplies. But times change, and to remain competitive, the family decided to specialize in toys in 1996. ?Toys have always been our strong point,? John Veach says.

Some things remain the same. Veach?s has been in the same location for about 70 years and still offers layaway so families can save up for the perfect Christmas gift ? a rarity today.

Personal attention and friendly customer service are keys to the store?s success over the years. Trying out toys is encouraged, and employees will open any box to show customers how to use what?s inside. ?We have unique games you won?t see on television, so you have to explain them,? Veach says.

They?ll even let you take a game home to try it out and see if you like it before buying. ?That makes us unique,? he says. ?We trust customers ? and they always bring it back.?

A 3-year-old boy at Veach's Toy Station in Richmond

That trust goes both ways, because customers constantly ask for recommendations on toys and games. ?We help the customer find the right gift, toy or workbook they need to help their child over the summer. We take the time to get to know the customers.?

One family makes the trek to this eastern Indiana town all the way from Florida twice a year to stock up on games that Veach personally suggests for them. ?They come back and ask, ?What?s a brand new game that we have not seen?? or, ?Show us something different.? It?s always a challenge to have something new for them,? he says.

Stories like this keep faithful customers coming back. Even when they grow up and move away, customers will ship toys from Veach?s to their children and grandchildren in other states.

In 2013, Veach?s turns 75 and will mark its anniversary with a special celebration for its customers. ?It?s going to be a yearlong birthday party,? he says. No doubt, it will include plenty of fun for the whole family.

Veach's Toy Station in Richmond

Visit Veach?s
Veach?s Toy Station is located at 715 East Main St. in Richmond. To learn more, visit www.veachstoystation.com or call (765) 962-5761.

Source: http://my-indiana-home.com/toy-story-veachs-celebrates-75-years/

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There are numerous of places - Atv Classifieds

Free Classifieds Automotive & Bike ATV

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Ad Listed On: Nov 09, 2012

Ad Views: 7

Location: Springfield Springfield SA Springfield Springfield SA

Tags: atv classifieds, automotive & bike advertisement

Classifieds category: Automotive & Bike

Source: http://www.adjingo.com/atv/free-ads-126361.html

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The Sensible Detox Diet

sensible-detox-dietPatients repeatedly ask me for advice on how to follow a detox diet.

I usually want to roll my eyes because it involves some kind of lemon juice diet or all lettuce diet.

So, I have created a guide on how to follow a more reasonable detox diet.

No more juice cleanses!

Now is the time to eat real foods that cleanse the body the healthy way.

Step 1: Get Rid of Added Sugars

sugar-in-foods

  • Look for every source of added sugars in your diet. This includes fruit flavored yogurts, flavored oatmeal packets, granola bars, most cereals, and sweetened beverages.
  • Look for the sugar names?on labels: Cane juice and cane syrup, corn sweeteners and high-fructose corn syrup, fruit juice concentrate and nectars, agave, and malt syrup. They all contain sugar.
  • Eliminate: Added sugars are not going to do anything to help detoxify your body.

One exception is real unprocessed?honey, which contains antibacterial properties.

Step 2: Load Up On Fruits and Vegetables

  • Fruits and vegetables contain fiber, antioxidants, vitamins, and minerals. There is a mysterious synergistic health benefit we get from eating the plant fiber and phytochemicals that detoxifies the body naturally.
  • Increasing you fruit and vegetable intake will help to keep you fuller, reduce your calories, and flush out toxins. An added bonus is that you will consume more potassium when eating more plants. This will help to reduce water weight.
  • Limit other animal products temporarily. Don?t forget to include plant proteins like legumes, beans, and quinoa to maintain muscle mass.. This will help to ensure efficient bowel movements.

Step 3: Avoid Diet Drinks or Other Diet Products

How are you supposed to ?detox? if you are putting chemical diet products back in the body. This simply can not be allowed. Even if the chemicals do not harm us, the idea is to eat clean, healthy, whole foods.

Good Detox Beverage Choices:

  • Water
  • Water with Lemon
  • Green tea
  • Pure 100% coconut water
  • Herbal teas

Step 4: ADD Potent Detox Foods

These are foods to include more of when you are trying to detoxify the body: lemon, lime, green tea,?apple cider vinegar, kale, blueberries, flax seeds, broccoli, and other berries. These are types of foods that are known for their high antioxidant and/or antibacterial properties.

I never truly recommend that people undergo a ?cleansing? diet. You should always check with your healthcare provider first. We should always try to eat healthy with some small moderation. But, I understand that some want a jump start to get past their old habits.

Following a stricter routine for a few days can help reset your priorities, but make sure you have a more realistic plan ready to go. We can?t live by detox diets alone!

Have you ever tried a detox diet before?

Source: http://www.diet-blog.com/12/the-sensible-detox-diet.php

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Friday, November 9, 2012

BPAP: PHL BPO industry to support US amid threat of anti ...

Despite speculations that re-elected US President Barack Obama intends to reopen debates over an anti-outsourcing bill in the US Congress, the Business Processing Association of the Philippines (BPAP) on Friday said it would continue supporting American businesses and the fragile US economy.
?
The Philippine outsourcing industry would continue helping American companies ?? to ensure they are among the most competitive in the world while freeing up resources to create more jobs in the US,? said BPAP president and CEO Benedict Hernandez.
?
By outsourcing non-core operations to Philippine-based providers, American companies become more profitable and competitive, Hernandez said.
?
"Profitable companies hire more workers, both here and in the United States," he said.
?
The ?Bring Jobs Home Act? failed to pass in the US Senate last July. Its goal was to remove tax incentives from US companies that outsource non-core operations and manufacturing jobs to other countries. If legislated, the law would give US companies a 20-percent tax deduction on costs associated with closing outsourced operations and transferring jobs to the US.
?
However, numerous studies have shown that outsourcing has little negative impact on job losses and in fact fosters job growth in companies that outsource business processes, according to BPAP.
?Dartmouth?s Tuck School of Business economist Matthew Slaughter, in a study of the hiring practices of 2,500 US multinationals, found that for every job outsourced, nearly two new jobs are created in the US,? Hernandez noted.
?
?
The global outsourcing industry is seen generating $220 billion in revenues this year $35 billion in 2009, according the Everest Group.
?
?Demand for global IT-BPO services is huge and continues to expand at a rapid rate,? Hernandez said.
?
?Outsourcing is a win-win proposition, and we believe that both American and Philippine companies ? and American and Filipino workers ? will continue to benefit from the opportunities it provides,? he added. ? VS, GMA News

Source: http://www.gmanetwork.com/news/story/281682/economy/business/bpap-phl-bpo-industry-to-support-us-amid-threat-of-anti-outsourcing-bill

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Thursday, November 8, 2012

Use Your Webcam For Home Surveillance With These Tools

free webcam surveillance softwareI live in England, the country with the highest number of CCTVs than anywhere else in the world ? about 1 camera to every 30 people, it?s estimated. Obviously, that?s not enough (yes, that is sarcasm), so today I?m doing a round-up review of useful tools for adding CCTV to your own home.

In all seriousness, having your own home surveillance system can be a powerful deterrent to would-be intruders or office workers who tend to pinch your stapler, but I don?t suggest using it to spy on your own family members.

A note About UK Law: It is perfectly legal to use CCTV for personal and home security, though you?d be advised not to point it at a neighbour?s property. There is no law against taking pictures or video in a public place including roads and pathways, and the Data Protection Act 1998 or Human Rights Act does not cover domestic usage of CCTV. However, there are exceptions to this rule if your camera is capable of remote-controlled movement. This isn?t relevant for most webcams, but many IP cameras can perform pan and tilt.

A Note About US Law: There are generally no restrictions on private use of security cameras. However there are exceptions in places where people might otherwise have an expectation of privacy ? such as bathrooms.

Active Webcam (Windows $29)

Ryan reviewed this back in 2009, and while it has a reasonable level of complexity, it looks like it hasn?t been updated since, so the interface and website are atrocious. Functional then, but better options below ? keep reading.

free webcam surveillance software

VitaminD Video (Mac and Windows)

Free for 1 camera, but at low resolution. $200 gets unlimited feeds at hi-resolution. At this price, I would have expected something amazing; though the interface is easy to understand ? rules that look for objects ? the actions available are severely limited to either recording a clip locally, playing a sound, or emailing you. Pathetic, forget this one.

webcam surveillance

iSpy (Windows ? Free/Premium)

Matt did a full review of iSpy last year, so I won?t repeat him here. It?s functional, but not nearly as advanced as some other apps. The software is free, but you?ll need to subscribe for $8/month for online access to view your feeds anywhere in the world (a function which many cameras and other apps provide for free).

One of the top benefits listed for subscribers is ?reduced ads?! Probably best to stay away from this one.

webcam surveillance

SecureCam (Open Source, Windows only)

Mark highlighted this back in 2009 ? but for a completely free setup, SecureCam is still a good option today. With support for 4 cameras (unlimited if you donate) and a built-in webserver to view the motion captured images and videos, it?s a fully functional and comprehensive solution, though lacking some of the shine of premium apps.

webcam surveillance

Yawcam (Windows, Free)

I wrote a full tutorial on using YawCam as a surveillance camera last year and even set up notifications on my iPhone, so read that for a full review. It?s not nearly as advanced as some of the other apps here, but it is free.

webcam surveillance software

Xeoma (Mac/Windows/Linux $30)

Xeoma is a comprehensive, cross-platform premium surveillance solution at an affordable price.?Functionality is added by the use of modules. For instance, you can add an email module to email you if motion is detected, or an alarm module to sound an alarm, or you could run a random application that triggers your arduino fog machine, laser cannon and strobe, scaring away the intruder.

It?s infinitely expandable, and can even emulate an IP camera to send its own output to another remote copy of itself. Genius.

webcam surveillance software

The software does come with a limited free mode or 30 day full evaluation period, a?$30 license is enough for up to 4 cameras.

webcam surveillance software

Although the interface is custom, I found Xeoma to be a reliable solution and easy to set up chains of custom events. This is one of the most powerful packages I?ve looked at, and is highly recommended.

Security Spy (OSX; ?30-?80)

Quite pricey, at ?30 for a single camera, ?80 for 4.?While I would love to have thoroughly tested this, unfortunately the app launched with the main windows far too large and wouldn?t allow me to resize; adding additional cameras was also buggy. Options seem quite limited, especially considering the price. Stay away from this one, there are far better ones out there.

EvoCam (OSX, $30)

EvoCam is an interesting solution but not particularly user-friendly; however it does contain more modular functionality similar to Xeoma. Actions sets are created which can act on one or more cameras ? these consist of an active time (if you only want recording at night, for instance), a condition (including sound triggers), and an action to perform (speak text, email an image, save a video).

It takes a while to get used to the control flow, but EvoCam is probably the most powerful of all these surveillance apps if you?re okay with it being OSX only. Do be sure to check functionality with your IP cam first though.

free webcam surveillance software

My personal choice is Xeoma, which is both affordable and very customizable. On the free side, you can?t really go wrong with YawCam or SecureCam, but don?t expect as many features.?I think that?s all of them, but do let me know if I missed your favourite surveillance software, free or otherwise.

Source: http://www.makeuseof.com/tag/webcam-home-surveillance-tools/

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Watch a NASA Astronaut Describe the Complexities of Photography in Space

Donald Pettit is, as well as being a NASA astronaut, an exceptionally keen photographer—which is why he has over 10 top-of-line DSLR cameras littering the International Space Station. In this video, he talks about the complexities, and joys, of photography in space. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/wDHxtiTgbps/watch-a-nasa-astronaut-describe-the-complexities-of-photography-in-space

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Looking for the anti-Alzheimer's molecule -- A new approach to treating a devastating disease

Looking for the anti-Alzheimer's molecule -- A new approach to treating a devastating disease [ Back to EurekAlert! ] Public release date: 7-Nov-2012
[ | E-mail | Share Share ]

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)

'In silico search for an endogenous anti-Alzheimer's molecule -- Screening amino acid metabolic pathways' published today in the Canadian Journal of Chemistry

Ottawa, Canada (November 7, 2012) Researchers at Dalhousie University have discovered a new technique using "computer-aided" drug design that may lead to an entirely new approach in the treatment of Alzheimer's disease (AD).

"Alzheimer's is a devastating disease for which no truly disease-modifying drugs are available. Our approach is completely novel. We explore how the human body attempts to protect itself from Alzheimer's, and then we exploit this to develop an entirely new approach to therapeutics," explained Dr. Weaver, a professor at Dalhousie University, clinical neurologist at Capital Health and IWK Health Centre, Canada Research Chair in Clinical Neuroscience, and the DMRF Irene MacDonald Sobey Chair in Curative Approaches to Alzheimer's Disease. "We are extremely excited about the results presented in this paper and believe that this may represent a new approach to the treatment of AD."

Weaver says that he and his fellow researchers have successfully identified molecules that are able to prevent the disease-producing aggregation of both beta-amyloid and tau the two proteins whose misfolding is implicated in the causation of Alzheimer's.

"Using 'in silico' (i.e. computer-aided) drug design, we have discovered new lead molecules that may aid in the future development of disease-modifying drugs for Alzheimer's disease," said Dr. Autumn Meek whose research into Alzheimer's has been funded by the Dalhousie Medical Research Foundation's "Gunn Family Graduate Studentship in Alzheimer's Disease". She works with co-authors Dr. Weaver and Mr. Gordon Simms in the Department of Chemistry at Dalhousie.

According to the Alzheimer's Society publication "Rising Tide: The Impact of Dementia on Canadian Society", Alzheimer's disease is an ever-growing concern in Canadian society, and as the population trends toward the aged it will place an increased strain on healthcare and families alike. It is believed that within a generation, the numbers of Canadians with Alzheimer's disease will more than double, and the cost of caring for individuals afflicted with dementia will increase from $15 billion annually to $153 billion annually.

###

The paper "In silico search for an endogenous anti-Alzheimer's molecule Screening amino acid metabolic pathways", published in the Canadian Journal of Chemistry.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Looking for the anti-Alzheimer's molecule -- A new approach to treating a devastating disease [ Back to EurekAlert! ] Public release date: 7-Nov-2012
[ | E-mail | Share Share ]

Contact: Jenny Ryan
jenny.ryan@nrcresearchpress.com
Canadian Science Publishing (NRC Research Press)

'In silico search for an endogenous anti-Alzheimer's molecule -- Screening amino acid metabolic pathways' published today in the Canadian Journal of Chemistry

Ottawa, Canada (November 7, 2012) Researchers at Dalhousie University have discovered a new technique using "computer-aided" drug design that may lead to an entirely new approach in the treatment of Alzheimer's disease (AD).

"Alzheimer's is a devastating disease for which no truly disease-modifying drugs are available. Our approach is completely novel. We explore how the human body attempts to protect itself from Alzheimer's, and then we exploit this to develop an entirely new approach to therapeutics," explained Dr. Weaver, a professor at Dalhousie University, clinical neurologist at Capital Health and IWK Health Centre, Canada Research Chair in Clinical Neuroscience, and the DMRF Irene MacDonald Sobey Chair in Curative Approaches to Alzheimer's Disease. "We are extremely excited about the results presented in this paper and believe that this may represent a new approach to the treatment of AD."

Weaver says that he and his fellow researchers have successfully identified molecules that are able to prevent the disease-producing aggregation of both beta-amyloid and tau the two proteins whose misfolding is implicated in the causation of Alzheimer's.

"Using 'in silico' (i.e. computer-aided) drug design, we have discovered new lead molecules that may aid in the future development of disease-modifying drugs for Alzheimer's disease," said Dr. Autumn Meek whose research into Alzheimer's has been funded by the Dalhousie Medical Research Foundation's "Gunn Family Graduate Studentship in Alzheimer's Disease". She works with co-authors Dr. Weaver and Mr. Gordon Simms in the Department of Chemistry at Dalhousie.

According to the Alzheimer's Society publication "Rising Tide: The Impact of Dementia on Canadian Society", Alzheimer's disease is an ever-growing concern in Canadian society, and as the population trends toward the aged it will place an increased strain on healthcare and families alike. It is believed that within a generation, the numbers of Canadians with Alzheimer's disease will more than double, and the cost of caring for individuals afflicted with dementia will increase from $15 billion annually to $153 billion annually.

###

The paper "In silico search for an endogenous anti-Alzheimer's molecule Screening amino acid metabolic pathways", published in the Canadian Journal of Chemistry.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/csp-lft110512.php

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'Modern Family' Star Ariel Winter -- Removed from Home After ...

Ariel Winter
Removed from Home
After Parental Abuse Allegations

EXCLUSIVE

1107-ariel-winter-tmz
Ariel Winter, the 14-year-old actress who plays Alex Dunphy on "Modern Family," has been removed from her home by a judge in the wake of serious allegations of physical and emotional abuse by her mother ... court sources tell TMZ.

There's a report Ariel is seeking legal emancipation from her mom so she can be with her boyfriend, but that report is false.

Court sources tell us ... on October 3rd, after a guardianship hearing, a judge determined the allegations that Ariel was being physically and emotionally abused by her mother Crystal Workman were serious enough that the judge placed Ariel in a temporary guardianship with her older sister Shanelle Workman. Our sources tell us ... mama Crystal was ordered to stay 100 yards away from Ariel.

Ironically, we've learned Shanelle suffered the same alleged abuse as Ariel.? Nearly two decades ago, the Department of Children and Family Services removed her from Crystal's home based on similar abuse allegations. Law enforcement sources tell us ...? D.C.F.S. placed Shanelle in foster care for more than 2 years.? She never went back to her mother.

According to court records, the judge has set another hearing for November 20.

Source: http://www.tmz.com/2012/11/07/modern-family-ariel-winter-child-services-abuse-mother/

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Wednesday, November 7, 2012

Insomnia doubles risk of heart attack, stroke, research shows

The study by researchers in Taiwan found that people with insomnia were twice as likely to have heart attacks or strokes than those without the sleep disorder during the trial's four-year period. The research was presented Monday at the American Heart Association meeting in Los Angeles.

The findings add to previous research showing not enough sleep can contribute to high blood pressure, and waking too early may raise heart risks. Sleep should be part of the patient-doctor discussion during checkups, said Kristen Knutson, a sleep researcher who wasn't part of the study.

"A lot of people and many physicians don't ask about sleep," said Knutson, an assistant professor in the Department of Medicine at the University of Chicago. "The first thing is to talk to their patients and also for the patients to talk to their doctors about their sleep and discussing sleep as one of the many important health behaviors like diet and exercise."

No one is certain how lack of sleep contributes to heart attacks and strokes, she said. It may be that the body's "fight or flight" system is more active with not enough sleep, which can increase heart rate and over time increase blood pressure and raise the risk for cardiovascular disease, she said.

Chronic insomnia affects about 1 in 5 adults and is also a risk factor for depression, substance abuse and impaired waking function, according to the National Institutes of Health.

Source: http://www.tulsaworld.com/site/articlepath.aspx?articleid=20121107_13_A12_Sleepd697245

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